Primary care physicians have a number of tools available to triage patients.
In addition to the published categorical guidelines available through professional organizations,[1-4] there are also red flag cards, paper-based checklists, and patient-directed online referral tools.
Note: A concerted effort is being made within the genetics community to shift terminology used to describe genetic variation.Patients are considered to be at "elevated" risk if the Pooled Cohort Equations predicted risk is ≥ 7.5%.In many ways, the Pooled Cohort Equations have been proposed to replace the Framingham Risk 10-year As shown above, among patients who do not otherwise have a compelling indication for statin therapy, the Pooled Cohort Equations can be used to estimate primary cardiovascular risk and potential benefit from statin therapy.Many include the commonly known features suggestive of hereditary cancers, but exclusions are noted in the table below.Risk management will reduce the likelihood and severity of serious and adverse health and safety outcomes.These include Armenia, Azerbaijan, Belarus, Bulgaria, Georgia, Kazakhstan, Kyrgyzstan, Latvia, Lithuania, Macedonia FYR, Moldova, Russia, Ukraine and Uzbekistan.*Updated, re-calibrated charts are now available for Belgium, Germany, Greece, The Netherlands, Spain, Sweden and Poland.Throughout this summary, we will use the term pathogenic variant to describe a disease-causing mutation.Refer to the Cancer Genetics Overview summary for more information about variant classification.] This summary describes current approaches to assessing and counseling people about their chance of having an inherited susceptibility to cancer.Criteria have been published to help identify individuals who may benefit from genetic counseling.[1,3] The PDQ cancer genetics information summaries on breast, ovarian, endometrial, colorectal, prostate, kidney, and skin cancers and endocrine and neuroendocrine neoplasias describe the clinical features of hereditary syndromes associated with these conditions.The following are features that suggest hereditary cancer:[4-8] It is important that individuals who are candidates for genetic testing undergo genetic education and counseling before testing to facilitate informed decision making and adaptation to the risk or condition.[1,7-13] Genetic education and counseling allows individuals to consider the various medical uncertainties, diagnosis, or medical management based on varied test results, and the risks, benefits, and limitations of genetic testing.