She then portrayed Zerelda Mimms in the Andrew Dominik film The Assassination of Jesse James by the Coward Robert Ford, which opened in cinemas in September 2007.
After receiving both Golden Globe and Primetime Emmy Awards for her portrayal of Harper Pitt on the acclaimed HBO television miniseries Angels in America in 2003, Parker went on to enjoy large success as Nancy Botwin, the lead role on the television series Weeds, which ran from 2005 to 2012 and for which she received three nominations for the Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series between 20 and received the Golden Globe Award for Best Actress – Television Series Musical or Comedy in 2006. Since 2007 Parker has contributed articles for Esquire magazine and later published her memoir, Dear Mr. In 2017, she starred as Roma Guy on the ABC television miniseries When We Rise.
After receiving the award, Parker stated: "I'm really in favor of legalizing marijuana.
I don't think it's that controversial." In March 2007, Parker played the lead role in the television film The Robber Bride.
In that category, she defeated the four leads of Desperate Housewives.
She dedicated the award to the late John Spencer, known for his work as Leo Mc Garry on The West Wing.